Working on scheduling a daylight Coyote hunt out West. My cartridge already chosen. It'll work...close and far.

My friend's 1 and only, long time rifle is a 30-06. It's accurate and he knows how to use it. 150 gr and up, he's well stocked. My question here is this: assuming HE and the rifle are MOA - and they are - can we hand-load a 125 gr bullet and not lose MOA accuracy? Speer & Sierra.

Not asking anyone to guarantee anything with all the many variables. Just asking for first-hand good or bad experience - which bullet - fps - powder preference - etc??

Thanks. Much appreciated.