I bowhunt and I don't mind a blood trail. With firearms I do what I can to avoid bones other than ribs coming and going, terming for both lungs and perhaps the heart. I'd rather walk 60 yards than loose a shoulder of meat.

Surprisingly I have had deer drop in their tracks with a roundball from a muzzleloader. The WORST possible sectional density and ballistic coefficient . . . but it goes in making a 0.54" hole and spends all the energy in the deer.

One was a frontal shot while I was sitting on the ground. The ball went in through the heart and lodged under the skin on the back side of a femur. 32" of penetration! The buck reared on on his hind legs and then collapsed.