So far I've found barrel length and twist are I won't say most important but they are very important... the longer your barrel, the slower burn rate you need to insure the pressure curve is extended the whole travel in the barrel. You don't want it burning out to soon otherwise you loose velosity to friction of bullet in the barrel and you don't want it burning to long because you are just wasting powder and if the pressure being produced is high enough, it can act as a tail wind blowing your projectile off center or causing wobble... twist of course partially determines how light or heavy of a slug your pressure can efficiently move... example... 10 twist will do better with heavier projectiles than a 12 twist will... you can to some degree offset these factors varying charge weights, OAL etc but a good starting point is to figure your length and twist and find what grain of bullet is conducive to those factors then start tweaking the other variables to really tighten your formula...me Lee (newest version) reload manual... here are some starters for 180gr bullets
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