Gunsmith I don't know. The round should extract and eject fine. The 22tcm is a really short .223 case. Since the Savage is a push feed it's likely that it will feed ok You can check this really easily. Find someone that has a Savage in .223 and run some 22tcm through it.
I'm not sure if there is anything to be had over the 221 Fireball. The 221 Firewall is the same case just a bit longer so it should have better ballistics than the 22tcm out of a rifle. If I were going to make a rifle like this...I would go for the .221 but if you have a 22tcm pistol I can kinda sorta see the efficiency of only having one cartridge to load.
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