The sights would probably not line up to top dead center, so they would need to be removed. Then you have a cosmetic flaw due to the screw holes. They would probably shoot every bit as good as barrels without sights, but some people don't want the cosmetic flaw.
The basic rule of supply and demand dictates that they are worth less. How much depends on the buyer, but I'd say about 25% less. My $.02.
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