Use at least an upper window ( 75%-80%) load for the parent 22-250. As P.O. said, "Use a good stiff load". What powder-bullet combination is up to you.
I don't do any development until I have formed brass. To form the last batch of 22-250 Imps I used Varget and some 45g Hornets I had laying around and some using Unique, TP and a soap bullet.
Bill
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