Still think the Ruger MK I/II/III series pistols are about the best out there for a 22 semi-auto. Yeah they're kind of a PITA to tear down and put back together, but they're dead-nuts accurate and there's a plethora of aftermarket parts available for them. The newer 22/45 models even have a more familiar 1911 grip angle if you don't care for the traditional Luger-like grip angle.
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