Yes, its why when changing or using another lot its wise to reduce the charge and work back up.
Here is the original bar chart I made while working up the load for my 270-08 Imp using Varget.
Notice there are two bars each for the 44 and 45 grain loading. The first what was left in a one pound can, the second from a new 8 pounder. BTW, they were shot in about the same timeframe, the same day using the same brass, lot of bullets and primers.
Bill
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