I prefer the boat tail bullets in the 22-250......Nosler 50g, Sierra 65g, and Sierra 52g MK. Probably one of the most accurate loads I've tried in the 22-250 is the 52g Sierra Matchking with H4895.
If you really want to try a flat base, look at the Sierra 60g HP or even the Berger offerings. I've never shot the Bergers out of a 22-250 so I can't recommend a specific bullet.
The Nosler 50g BT and R-15 combo is pretty hard to beat though......
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