2.650 will work if you are carefull but in field conditions will give you trouble sooner or later. Luckily my two 243s prefer them seated to 2.625 8) Even though I load them into single shots they are packaged in balk bags for shootin prairie dogs, have yet to have one come apart.
Hodgdon says you can get more speed out of H380 but H414 has proven to be a better choice.
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