Physical Difference Between .17 WSM 20 and 25 grain.

Bought at the start of winter, I have had very little time on the Bmag. No time on hunting with it. Just looking for some input on the actual difference between the 20 and 25 grain bullet.
here's the explanation:
The .17 Winchester Super Magnum offers the downrange performance of a centerfire cartridge at only a fraction of the cost. For the first time in history, hunters can expect pinpoint accuracy and devastating performance from a rimfire cartridge at ranges well past 200 yards. The Varmint High Velocity(HV) reaches up to a blistering 3000 FPS, and delivers explosive expansion upon impact. The Varmint High Energy(HE) provides maximum shock and deep penetration.
So do we stick to the HV for rodents? Rabbits maybe? And the HE for bigger? Coyotes and the like? Or would it really matter?