Chambers variations have a big part in increasing chamber pressures.
That is the probable cause.
When my new 12 LRP in 6.5mm Creedmoor arrived, it shot factory ammo (Federal Gold Match, Norma and Hornady) accurately but flattened the primers.
As I began reloading for it, I found that it was flattening primers even when I loaded at muzzle velocities lower than factory.
Fortunately, I photographed the ammo and the primers when I removed them and noticed that the primer backs has a ridge on them, like they were being pushed back out of the primer pocket into the bolt face.
After finding that the primer pockets were worn out after 4 reloads or less, I contacted Hornady and asked them, the originator of the caliber, whether that was normal.
They told me that a tight chamber, often used in rifles to gain accuracy, might be the problem.
I contacted Savage and sent them the pictures of the primers and the bases of the fired ammo at different pressures. Even loads at the low end of the load tables exhibited flattened primers. Savage had me send back the rifle and they reamed out the chamber by a few thousands.
The adjusted chamber eliminated the flattening even at loads near PMax.
I have 5 Savages and this is the only one that had anything like these symptoms.
Powders strength can vary by as much as 10%, although that much of a variation is rare. But a 5% variation is possible.
Assuming a nominal powder lot, your original load of 43.5 grains of IMR4604 with 168 grain bullets would generate around 54,183 psi. Using a load of 44.5 grains of IMR4064 would generate around 58,104 psi. That is at 93.7% of PMax.
It could be you also had a lot of IMR4064 that is a bit hot that caused some of the problem.
But it easily could be a combination of a hotter powder lot and a chamber that is slightly tight (or in your case off center).
On last thing, shooting in high temperature conditions can change the chamber pressure significantly.
Shooting at 90 degrees versus 70 degrees would get you 3% closer to PMax.
Cold weather, in this case, is your friend.