switch barrel accuracy

I am thinking of getting a 308 barrel to add to my savage which is currently sporting a 243 win. I have worked up a load that produces 1/2 inch groups at 100 yards. If i switch to the 308 barrel and then put the 243 back on, will the accuracy still be there or will i have to work up the load again? For those of you that have a switch barrel gun, do you have to rezero your scope everytime you switch out the barrels?

thanks

On my three barrels the accuracy is still there. in all probably, you'll never see the difference, but I'm not a BR shooter.

you will have to "tweak" the scope sighting again.

just my experience